Abstract: The sinusoidal plus residual noise model is used to modulate harmonic components of dynamic music signals of different instruments. The subjective evaluation experiment is carried out to compare the auditory sensation indicators of consonance, roughness, naturalness and sharpness with different modulation modes. The results show that the effect of harmonic modulation on the sense of consonance is consistent in different timbre types, and the sense of consonance is related to the mode of harmonic modulation.